research progress on anti-tumor activity of lactic acid

Research Progress on Chemical Constituents of Zingiber

Zingiber officinale Roscoe is commonly used in food and pharmaceutical products but can also be used in cosmetics and daily necessities In recent years many scholars have studied the chemical composition of Zingiber officinale Roscoe therefore it is necessary to comprehensively summarize the chemical composition of Zingiber officinale/i Roscoe in one article

Multiple Biological Activities of Lactic Acid in Cancer

Title: Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth Angiogenesis and Metastasis VOLUME: 18 ISSUE: 10 Author(s):Suveera Dhup Rajesh Kumar Dadhich Paolo Ettore Porporato and Pierre Sonveaux Affiliation:Universite catholique de Louvain (UCL) Medical School Institute of Experimental and Clinical Research (IREC) Pole of Pharmacology Avenue Emmanuel

Evaluation of Antioxidant and Antitumor Activities of

In vitro assessment of anti tumor activity of L acidophillus bacteria and its EPS Tumor cells: The initial inoculums of Ehrlich Ascites Carcinoma (EAC) were purchased from the National Cancer Institute Cairo University Egypt EAC cells were propagated in NODCAR laboratories by weekly intraperitoneal injection of 0 2 of 1:5 mL-1 saline solution of freshly drawn ascetic fluid (0 2x10 6 EAC

Broad and complex antifungal activity among environmental

The concentration of acetic acid in the samples 29–31 mM corresponds to the amount present in MRS broth The highest concentrations of lactic acid 90 and 95 mM were observed with the two isolates with the lowest antifungal activity The three isolates with high antifungal activity produced low amounts of lactic acid (60 62 and 62 mM)

Treatment of Lactic Acidosis

Lactic acidosis (LA) is common in hospitalized patients and is associated with a high mortality 1 2 Commonly it is defined as a lactic acid concentration greater than 5 mmol/L with a pH less than 7 35 3 There are no evidence‐based guidelines for the treatment of LA despite progress in our understanding of its pathophysiology 36 This is not surprising given the uncertainty regarding the

Current Limitations and Challenges with Lactic Acid

tance of controlling the metabolic activity of LAB this paper thus aimed to review the recent research in the relationship between the metabolic activity and nutri-tional requirements of LAB and to highlight the associ-ated limitations and challenges 2 Metabolic Activity of Lactic Acid Bacteria

Role of dendritic cell metabolic reprogramming in tumor

Introduction Dendritic cells (DCs) play a critical role in the generation of anti-tumor immunity () Indeed recent data have shown the DC to be essential for the generation of effector T-cell responses to checkpoint inhibitor immunotherapy () Therefore our understanding of the biochemical pathways that tumors leverage to interfere with DC function now has direct therapeutic relevance ()

Broad and complex antifungal activity among environmental

The concentration of acetic acid in the samples 29–31 mM corresponds to the amount present in MRS broth The highest concentrations of lactic acid 90 and 95 mM were observed with the two isolates with the lowest antifungal activity The three isolates with high antifungal activity produced low amounts of lactic acid (60 62 and 62 mM)

Antifungal activity of two Lactobacillus strains with

Lactic acid bacteria are known to produce various antimicrobial compounds that are considered to be important in the biopreservation of food and feed Lactobacillus rhamnosus L60 and Lactobacillus fermentum L23 are producers of secondary metabolites such as organic acids bacteriocins and in the case of L60 hydrogen peroxide

Exopolysaccharides produced by lactic acid bacteria and

Sep 01 2019Exopolysaccharides (EPSs)-producing lactic acid bacteria (LAB) and Bifidobacteria are widely used as starter cultures to make fermented food products due to their technological benefits Moreover LAB-EPSs and bifido-EPSs have been demonstrated to possess various physiological functions such as antioxidant anticancer antibacterial and immunological activities among which the

Targeting T cell metabolism in the tumor microenvironment

Sep 13 2019Glucose competition amino acid competition oxygen competition and lactic acid secretion in the tumor microenvironment promote formation of the immunosuppressive phenotype Therefore determining the influence of the tumor microenvironment on T cell metabolism will be helpful for developing methods to enhance the anti-tumor effect of T cells

Food

One of the most promising areas of development in the human nutritional field over the last two decades has been the use of probiotics and recognition of their role in human health and disease Lactic acid-producing bacteria are the most commonly used probiotics in foods It is well known that probiotics have a number of beneficial health effects in humans and animals

Tumor cell energy metabolism and its common features with

During the last decades a considerable amount of research has been focused on cancer A number of genetic and signaling defects have been identified This has allowed the design and screening of a number of anti-tumor drugs for therapeutic use One of the main challenges of anti-cancer therapy is to

Cancer generated lactic acid: Novel therapeutic approach

Normalizing cancer generated lactic acid and resultant acidification and focusing on altered metabolic pathway may lead to cancer inhibition Considering this hypothesis that regulation of lactic acid production may lead to a positive effect on control of cancerous growth studies are on progress to find the inhibitors of aerobic glycolysis

Abstract 3022: BAY 1143572 a first

BAY 1143572 a first-in-class highly selective potent and orally available inhibitor of PTEFb/CDK9 currently in Phase I shows convincing anti-tumor activity in preclinical models of acute myeloid leukemia (AML) [abstract] In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research 2016 Apr 16-20 New

Catechol derived from aronia juice through lactic acid

This study isolated and investigated a new cancer stem cell (CSC) inhibitor derived from lactic acid fermentation products using culture broth with 2% aronia juice The anti‐CSC activity of aronia‐cultured broth was significantly higher than that of the control

Importance of lactic acid bacteria in Asian fermented

Aug 30 2011Lactic acid bacteria play important roles in various fermented foods in Asia Besides being the main component in kimchi and other fermented foods they are used to preserve edible food materials through fermentation of other raw-materials such as rice wine/beer rice cakes and fish by producing organic acids to control putrefactive microorganisms and pathogens

Food

One of the most promising areas of development in the human nutritional field over the last two decades has been the use of probiotics and recognition of their role in human health and disease Lactic acid-producing bacteria are the most commonly used probiotics in foods It is well known that probiotics have a number of beneficial health effects in humans and animals

Lactic Acid Production using Food Waste – IJERT

combination like calcium sodium or iron exhibit anti- tumor activity [21] The use of lactic acid in intravenous injections acts as bodily electrolyte which replenishes bodily fluids Lactic acid is also used as a lactated Ringers or Hartmanns solution in artificial kidney machines [22] Polylactic acid has potential to work as drug releasing

Cultivation media for lactic acid bacteria used in dairy

Nov 14 2019This review aims to familiarize the reader with research efforts on the cultivation media of lactic acid bacteria (LAB) We have also included a brief discussion on standard ingredients used in LAB media and chemically defined media as related to bacterial growth requirements

Research Progress on Chemical Constituents of Zingiber

Zingiber officinale Roscoe is commonly used in food and pharmaceutical products but can also be used in cosmetics and daily necessities In recent years many scholars have studied the chemical composition of Zingiber officinale Roscoe therefore it is necessary to comprehensively summarize the chemical composition of Zingiber officinale/i Roscoe in one article

Fermented and vegetables A global perspective Chapter 5

5 2 1 Lactic acid fermentation The lactic acid bacteria belong to two main groups – the homofermenters and the heterofermenters The pathways of lactic acid production differ for the two Homofermenters produce mainly lactic acid via the glycolytic (Embden–Meyerhof) pathway)

Antioxidative Ability of Lactic Acid Bacteria

Nineteen strains of lactic acid bacteria were investigated for antioxidative activity These included Lactobacillus acidophilus B E N1 4356 LA-1 and Farr Lactobacillus bulgaricus 12 278 448 449 Lb 1006 and 11 842 Streptococcus thermophilus 821 MC 573 3641 and 19 987 and Bifidobacterium longum B6 and 15 708 Intracellular cell-free extract of all strains demonstrated

Importance of lactic acid bacteria in Asian fermented

Aug 30 2011Lactic acid bacteria play important roles in various fermented foods in Asia Besides being the main component in kimchi and other fermented foods they are used to preserve edible food materials through fermentation of other raw-materials such as rice wine/beer rice cakes and fish by producing organic acids to control putrefactive microorganisms and pathogens

New Progress regarding the Use of Lactic Acid Bacteria as

Lactobacillus species are non-spore-forming gram-positive bacteria and lactic acid producing bacteria (LAPB) that naturally inhabit the human and animal gastrointestinal and mouth organs The aim of this review was to evaluate the new progress regarding the use of Lactobacillus species as live delivery vectors prevention and treatment of pathogenic and metabolic diseases

Targeting T cell metabolism in the tumor microenvironment

Sep 13 2019Glucose competition amino acid competition oxygen competition and lactic acid secretion in the tumor microenvironment promote formation of the immunosuppressive phenotype Therefore determining the influence of the tumor microenvironment on T cell metabolism will be helpful for developing methods to enhance the anti-tumor effect of T cells

The tumor microenvironment as a

May 05 2020High lactate concentrations produced by tumor cells impeded lactic acid export in CD8 + T cells and thus suppressed their effector function (Fischer et al 2007) Tumor-associated expression of lactate dehydrogenase A is associated with lower survival and impaired T cell activity in melanoma patients ( Brand et al 2016 )